There is no shortage of excitement on today’s MLB schedule, including the San Diego Padres taking on the Los Angeles Dodgers.

For a breakdown of all the big games in the MLB today, dive into our betting odds preview below.

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MLB Betting Info Today – Sept. 25

Seattle Mariners (81-77) at Houston Astros (86-72)

Betting Info & Picks

• Moneyline Favorite: Astros -135
• Moneyline Underdog: Mariners +110
• Total: 8 Runs (+100 to go over, -120 to go under)
• Prediction: Astros 5, Mariners 4
• Moneyline Pick: Astros (-135) over the Mariners (+110)
• Total Pick: Over 8 Runs

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How to Watch

• TV Channel: SCHN
• Live Stream: Watch on Fubo (Regional restrictions may apply)
• Game Time: 2:10 PM ET
• Venue: Minute Maid Park
• Location: Houston, Texas
• Astros Starter: Yusei Kikuchi (9-9, 4.19 ERA)
• Mariners Starter: George Kirby (13-11, 3.6 ERA)

Chicago Cubs (81-77) at Philadelphia Phillies (93-65)

Betting Info & Picks

• Moneyline Favorite: Phillies -190
• Moneyline Underdog: Cubs +155
• Total: 8 Runs (-115 to go over, -105 to go under)
• Prediction: Phillies 5, Cubs 4
• Moneyline Pick: Phillies (-190) over the Cubs (+155)
• Total Pick: Over 8 Runs

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How to Watch

• TV Channel: MARQ
• Live Stream: Watch on Fubo (Regional restrictions may apply)
• Game Time: 6:05 PM ET
• Venue: Citizens Bank Park
• Location: Philadelphia, Pennsylvania
• Phillies Starter: Cristopher Sanchez (11-9, 3.25 ERA)
• Cubs Starter: Javier Assad (7-5, 3.34 ERA)

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Cincinnati Reds (76-82) at Cleveland Guardians (91-67)

Betting Info & Picks

• Moneyline Favorite: Guardians -150
• Moneyline Underdog: Reds +125
• Total: 8.5 Runs (+100 to go over, -120 to go under)
• Prediction: Guardians 5, Reds 4
• Moneyline Pick: Guardians (-150) over the Reds (+125)
• Total Pick: Under 8.5 Runs

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How to Watch

• TV Channel: BSGL
• Live Stream: Watch on Fubo (Regional restrictions may apply)
• Game Time: 6:40 PM ET
• Venue: Progressive Field
• Location: Cleveland, Ohio
• Guardians Starter: Joey Cantillo (2-3, 4.63 ERA)
• Reds Starter: Jakob Junis (4-0, 2.61 ERA)

Milwaukee Brewers (90-67) at Pittsburgh Pirates (73-84)

Betting Info & Picks

• Moneyline Favorite: Brewers -150
• Moneyline Underdog: Pirates +125
• Total: 7.5 Runs (-115 to go over, -105 to go under)
• Prediction: Brewers 5, Pirates 4
• Moneyline Pick: Brewers (-150) over the Pirates (+125)
• Total Pick: Over 7.5 Runs

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How to Watch

• TV Channel: SportsNet PT
• Live Stream: Watch on Fubo (Regional restrictions may apply)
• Game Time: 6:40 PM ET
• Venue: PNC Park
• Location: Pittsburgh, Pennsylvania
• Pirates Starter: Luis Ortiz (6-6, 3.43 ERA)
• Brewers Starter: Freddy Peralta (11-8, 3.69 ERA)

Tampa Bay Rays (78-79) at Detroit Tigers (83-74)

Betting Info & Picks

• Moneyline Favorite: Tigers -115
• Moneyline Underdog: Rays -105
• Total: 8 Runs (-105 to go over, -125 to go under)
• Prediction: Tigers 5, Rays 4
• Moneyline Pick: Tigers (-115) over the Rays (-105)
• Total Pick: Over 8 Runs

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How to Watch

• TV Channel: BSDET
• Live Stream: Watch on Fubo (Regional restrictions may apply)
• Game Time: 6:40 PM ET
• Venue: Comerica Park
• Location: Detroit, Michigan
• Tigers Starter: Keider Montero (6-6, 4.86 ERA)
• Rays Starter: Zack Littell (8-9, 3.56 ERA)

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Kansas City Royals (83-74) at Washington Nationals (69-88)

Betting Info & Picks

• Moneyline Favorite: Royals -115
• Moneyline Underdog: Nationals -105
• Total: 7.5 Runs (-120 to go over, +100 to go under)
• Prediction: Royals 6, Nationals 5
• Moneyline Pick: Royals (-115) over the Nationals (-105)
• Total Pick: Over 7.5 Runs

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How to Watch

• TV Channel: MASN2
• Live Stream: Watch on Fubo (Regional restrictions may apply)
• Game Time: 6:45 PM ET
• Venue: Nationals Park
• Location: Washington, District of Columbia
• Nationals Starter: DJ Herz (4-8, 4.3 ERA)
• Royals Starter: Michael Lorenzen (7-6, 3.43 ERA)

Baltimore Orioles (87-70) at New York Yankees (92-65)

Betting Info & Picks

• Moneyline Favorite: Yankees -145
• Moneyline Underdog: Orioles +120
• Total: 8 Runs (-115 to go over, -105 to go under)
• Prediction: Yankees 5, Orioles 4
• Moneyline Pick: Yankees (-145) over the Orioles (+120)
• Total Pick: Over 8 Runs

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How to Watch

• TV Channel: YES
• Live Stream: Watch on Fubo (Regional restrictions may apply)
• Game Time: 7:05 PM ET
• Venue: Yankee Stadium
• Location: The Bronx, New York
• Yankees Starter: Nestor Cortes Jr. (9-10, 3.77 ERA)
• Orioles Starter: Zach Eflin (10-9, 3.53 ERA)

Boston Red Sox (80-78) at Toronto Blue Jays (73-85)

Betting Info & Picks

• Moneyline Favorite: Blue Jays -145
• Moneyline Underdog: Red Sox +120
• Total: 8 Runs (-105 to go over, -115 to go under)
• Prediction: Blue Jays 5, Red Sox 4
• Moneyline Pick: Blue Jays (-145) over the Red Sox (+120)
• Total Pick: Over 8 Runs

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How to Watch

• TV Channel: NESN
• Live Stream: Watch on Fubo (Regional restrictions may apply)
• Game Time: 7:07 PM ET
• Venue: Rogers Centre
• Location: Toronto, Ontario
• Blue Jays Starter: Kevin Gausman (13-11, 3.91 ERA)
• Red Sox Starter: Richard Fitts (0-0, 0 ERA)

New York Mets (87-70) at Atlanta Braves (86-71)

Betting Info & Picks

• Moneyline Favorite: Braves -190
• Moneyline Underdog: Mets +155
• Total: 7.5 Runs (-105 to go over, -115 to go under)
• Prediction: Braves 4, Mets 3
• Moneyline Pick: Braves (-190) over the Mets (+155)
• Total Pick: Under 7.5 Runs

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How to Watch

• TV Channel: SNY
• Live Stream: Watch on Fubo (Regional restrictions may apply)
• Game Time: 7:20 PM ET
• Venue: Truist Park
• Location: Atlanta, Georgia
• Braves Starter: Chris Sale (18-3, 2.38 ERA)
• Mets Starter: David Peterson (9-3, 3.08 ERA)

Los Angeles Angels (63-94) at Chicago White Sox (37-120)

Betting Info & Picks

• Moneyline Favorite: Angels -120
• Moneyline Underdog: White Sox +100
• Total: 8.5 Runs (-110 to go over, -110 to go under)
• Prediction: Angels 6, White Sox 5
• Moneyline Pick: Angels (-120) over the White Sox (+100)
• Total Pick: Over 8.5 Runs

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How to Watch

• TV Channel: BSW
• Live Stream: Watch on Fubo (Regional restrictions may apply)
• Game Time: 7:40 PM ET
• Venue: Guaranteed Rate Field
• Location: Chicago, Illinois
• White Sox Starter: Davis Martin (0-5, 4.27 ERA)
• Angels Starter: José Suarez (1-2, 6.08 ERA)

Miami Marlins (58-99) at Minnesota Twins (81-76)

Betting Info & Picks

• Moneyline Favorite: Twins -200
• Moneyline Underdog: Marlins +165
• Total: 8 Runs (-115 to go over, -105 to go under)
• Prediction: Twins 5, Marlins 4
• Moneyline Pick: Twins (-200) over the Marlins (+165)
• Total Pick: Over 8 Runs

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How to Watch

• TV Channel: BSFL
• Live Stream: Watch on Fubo (Regional restrictions may apply)
• Game Time: 7:40 PM ET
• Venue: Target Field
• Location: Minneapolis, Minnesota
• Twins Starter: Simeon Woods Richardson (5-5, 4 ERA)
• Marlins Starter: Edward Cabrera (4-8, 5.12 ERA)

St. Louis Cardinals (80-77) at Colorado Rockies (60-97)

Betting Info & Picks

• Moneyline Favorite: Cardinals -135
• Moneyline Underdog: Rockies +110
• Total: 10 Runs (-115 to go over, -105 to go under)
• Prediction: Cardinals 6, Rockies 5
• Moneyline Pick: Cardinals (-135) over the Rockies (+110)
• Total Pick: Over 10 Runs

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How to Watch

• TV Channel: BSMW
• Live Stream: Watch on Fubo (Regional restrictions may apply)
• Game Time: 8:40 PM ET
• Venue: Coors Field
• Location: Denver, Colorado
• Rockies Starter: Austin Gomber (5-11, 4.67 ERA)
• Cardinals Starter: Erick Fedde (8-9, 3.38 ERA)

Texas Rangers (74-82) at Oakland Athletics (67-89)

Betting Info & Picks

• Moneyline Favorite: Athletics -120
• Moneyline Underdog: Rangers +100
• Total: 7.5 Runs (-115 to go over, -105 to go under)
• Prediction: Athletics 4, Rangers 3
• Moneyline Pick: Athletics (100) over the Rangers (-120)
• Total Pick: Under 7.5 Runs

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How to Watch

• TV Channel: BSSW
• Live Stream: Watch on Fubo (Regional restrictions may apply)
• Game Time: 9:40 PM ET
• Venue: Oakland-Alameda County Coliseum
• Location: Oakland, California
• Athletics Starter: Brady Basso (1-0, 2.33 ERA)
• Rangers Starter: Cody Bradford (6-3, 3.59 ERA)

San Francisco Giants (78-79) at Arizona Diamondbacks (87-70)

Betting Info & Picks

• Moneyline Favorite: Diamondbacks -225
• Moneyline Underdog: Giants +185
• Total: 8.5 Runs (-115 to go over, -105 to go under)
• Prediction: Diamondbacks 5, Giants 4
• Moneyline Pick: Diamondbacks (-225) over the Giants (+185)
• Total Pick: Over 8.5 Runs

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How to Watch

• TV Channel: ARID
• Live Stream: Watch on Fubo (Regional restrictions may apply)
• Game Time: 9:40 PM ET
• Venue: Chase Field
• Location: Phoenix, Arizona
• Diamondbacks Starter: Zac Gallen (13-6, 3.74 ERA)
• Giants Starter: Mason Black (1-4, 5.88 ERA)

San Diego Padres (90-66) at Los Angeles Dodgers (93-63)

Betting Info & Picks

• Moneyline Favorite: Dodgers -145
• Moneyline Underdog: Padres +120
• Total: 7.5 Runs (-115 to go over, -105 to go under)
• Prediction: Dodgers 5, Padres 4
• Moneyline Pick: Dodgers (-145) over the Padres (+120)
• Total Pick: Over 7.5 Runs

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How to Watch

• TV Channel: SDPA
• Live Stream: Watch on Fubo (Regional restrictions may apply)
• Game Time: 10:10 PM ET
• Venue: Dodger Stadium
• Location: Los Angeles, California
• Dodgers Starter: Jack Flaherty (13-7, 3.1 ERA)
• Padres Starter: Dylan Cease (14-11, 3.42 ERA)

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