Deadly tornadoes roared through Alabama on Thursday, toppling trees, demolishing homes and knocking out power to thousands, part of a broad swath of violent weather sweeping across the Deep South. At least three fatalities and an unknown number of injuries were reported.

Firefighters said a family was able to safely escape their toppled home in the Eagle Point subdivision, near Birmingham. In the nearby city of Pelham, also in Shelby County, authorities posted video and photos showing large trees blocking roads and damaged utility poles leaning menacingly over streets littered with debris from badly damaged homes. More than 20,000 customers were without power in Alabama.

“We can confirm local residential structures have been completely destroyed,” Shelby County, Alabama, Sheriff John Samaniego told The Associated Press in an email.

Search and rescue efforts were complicated as strong weather continued to rake across the region.

“We have been told to be prepared for another round of storms,” said Maj. Clay Hammac of the Shelby County sheriff’s department.

Forecasters warned of dangerous thunderstorms, flash floods and possible twisters from eastern Mississippi into western Georgia, and northward into Tennessee and Kentucky. Flash flood warnings and watches extended to the western Carolinas. Alabama Gov. Kay Ivey issued an emergency declaration for 46 counties as the severe weather approached, and officials opened shelters in and around Birmingham.

Up to 4 inches (10 centimeters) of rain — with higher amounts possible — is expected in northern Alabama, according to the National Weather Service in Huntsville.

State troopers closed all lanes of a section of Interstate 65 near Cullman after floodwaters covered the roadway. The highway was reopened later in the day.

Mississippi also had a storm-related death on Wednesday. Ester Jarrell, 62, died when a large tree toppled over onto her mobile home after heavy rain soaked the ground, a Wilkinson County official told The Associated Press.